Texas Hepatocellular Carcinoma Consortium
The Texas Hepatocellular Carcinoma Consortium (THCCC) was established to reduce the burden and mortality of hepatocellular cancer (HCC) in Texas. The THCCC includes researchers from Baylor College of Medicine, MD Anderson in Houston, UT Southwestern Medical Center, Parkland Health Hospital System in Dallas, and UT San Antonio.
Building on the Quality in the Continuum of Cancer Care framework, our proposed THCCC targets key areas of uncertainty in the prevention and early detection of HCC. Primary prevention and early detection of HCC need to target high-risk individuals. For example, most cases of HCC (90%) arise in the background of cirrhosis, which is the main predisposing condition for HCC.
However, only 2-5% of persons with cirrhosis develop HCC annually. Thus, there is a pressing need to better risk-stratify cirrhosis patients for HCC. Yet, no such tools exist because most prospective studies of patients with cirrhosis fail to examine the full range of demographic, clinical, epidemiological, biochemical, and genetic factors that predict HCC. Our THCCC will fill this need by identifying a set of risk stratification indices for HCC in cirrhosis.
The goal of the Texas Hepatocellular Carcinoma Consortium (THCCC) is to reduce the death and suffering related to liver cancer in Texas and the world by conducting cutting edge collaborative research.
A main source of synergy and efficiency in the THCCC is the assembly of the largest prospective cohort study (of patients with cirrhosis) in the U.S. with sufficient power to address immediate questions regarding risk stratification, surveillance uptake, and early detection as well as provide platform for addressing future questions regarding Hepatocellular Carcinoma (HCC) prognosis and treatment. The proposed studies require the accurate, timely and consistent enrollment of a large number of patients in several study sites to answer critical questions in HCC.
Project 1. Risk Factors of Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease
We will use Texas VA datasets to assemble the largest NAFLD-to-HCC study to date
(Including over 45,000 NAFLD patients in Texas) to determine the number of patients to develop HCC and to identify factors that increase patients’ risk for HCC.
Project 2: Metabolic Syndrome and Risk Prediction of Hepatocellular Carcinoma
This project will develop risk stratification algorithms based on demographic, clinical, molecular and epidemiological risk factors to identify cirrhosis patients who might benefit from prevention or intensive surveillance. We will evaluate molecular and genotypic aspects of the metabolic syndrome as well as established risk factors.
Project 3: Circadian Disruption and Bile Acids as HCC Risk Factors
This project will identify pathways for chemoprevention related to the role of circadian rhythm and bile acids in NAFLD, metabolic syndrome, and HCC.
Project 4: Novel Biomarkers for Hepatocellular Carcinoma
This project will identify and validate novel blood markers (tests) for early HCC detection. We will also validate promising existing markers, and discover novel biomarkers for HCC detection.
We propose the first multi-center outreach intervention aimed at improving surveillance process completion among at-risk patients with cirrhosis.
Baylor College of Medicine
Houston VA Medical Center
Dr. Hashem El-Serag
Dr. Fasiha Kanwal
Dr. David Moore
University of Texas Southwestern Medical Center
Dr. Jorge Marrero
Dr. Amit Singal
University of Texas San Antonio
Dr. Fred Poordad
M.D. Anderson Cancer Center
Dr. Ziding Feng
Dr. Laura Beretta
University of Texas, Southwestern
Dr. Jorge A. Marrero, M.D., M.S.
Meetings / Events
THCCC 2016 Conference: Save The Date!
References and Publications
Frequently Asked Questions
1. How to get access to secure Web site?
To access the secure Web site, a user must be approved by a responsible project leader for each institution and vetted by the data management coordination center. Please send a request via email to ACastonguay@mdanderson.org.
2. What would I expect if I have submitted my access request?
You will soon receive a set of instructional emails for you to take action. You will need to complete the online account registration by: following the instructions, setup the security questions and answers, and choosing your own password.
3. What if I have forgotten my password?
Please use this link for password self-support services.
For step by step instructions on how to change your password or reset your forgotten password, Click Here.
4. What should I do if I have followed instructions but still having issues?
You can send your questions to firstname.lastname@example.org. Please include a detailed description of your issues.
5. What kind of browser I should use?
Please use Internet Explorer (IE) version 8 or above to process registration steps for secure site access. You may encounter problems if you are using other browsers. For Mac users unable to use IE, the Safari browser provides the greatest reliability.
6. How can I subscribe into a working email group?
You must first get access to the secure Web site in order to subscribe to the working group email list. Click Here to subscribe or unsubscribe to the CPDPC working groups.
Note: if you want to subscribe to either the executive committee (EC) or steering committee (SC) groups for CPDPC, please send an email to ACastonguay@mdanderson.org.
Step by step instructions on how to subscribe/unsubscribe can be found here.
7. Where can I find the working group email addresses?
You can find all working group email addresses onto the secure Web site. Click Here to see the list of email addresses for the CPDPC.
8. How do I join a WebEx Meeting?
Webex has provided several videos to assist you in joining a meeting.
Click Here to learn how to join the meeting as an Attendee.
Click Here to learn how to join a meeting from your mobile device.
Click Here for help connecting to the audio portion of your meeting.
Center of Data Management Coordination
Alicia Castonguay, PhD.
Associate Director, Research Planning and Development
Meetings and Events
Reference and Publications
Frequently Asked Questions
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